This peptide is derived from residues 14-21 of protein kinase C C2 (epsilonPKC C2). This peptide specifically inhibits epsilon-PKC by disrupting PKC binding to its receptor, RACK2. epsilonPKC mediated signal transduction plays a role in cell proliferation, differentiation, and apoptosis.SEQUENCE: H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH (trifluoroacetate salt)ONE-LETTER SEQUENCE: EAVSLKPTMOLECULAR FORMULA: C37H65N9O13MOLECULAR WEIGHT: 844.0STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [182683-50-7]SYNONYMS: PKC Inhibitor PeptideRESEARCH AREA: Protein Kinases and PhosphatasesREFERENCES:Lamy, C. et al. Tetrahedron Lett. 46, 6177 (2007)
Brandman, R. et al. J. Biol. Chem. 282, 4113 (2007)SKU(s): PPEP-004A